Powder in Soft Gels with Technophar

Encapsulating Powder Active Ingredients in Soft Gel Capsules

Since soft gels are designed to hold liquids, suspensions, or semi-solid fills, powders cannot be directly encapsulated unless they are first converted into a suitable form.

 

Methods of Encapsulating Powdered Actives in Soft gels:

    1. Suspension in Lipid/Oil-Based Carriers: The powder is dispersed in a lipid-based carrier (e.g., MCT oil, vegetable oils, PEG, or surfactants). Examples: Fat-soluble vitamins (Vitamin D, K), and herbal extracts.
    2. Solution in Solvents: If the powder is soluble in oil or water-miscible solvents, it is dissolved before encapsulation. Examples: Some APIs, Coenzyme Q10.
    3. Self-Emulsifying Drug Delivery Systems (SEDDS): Powders are formulated into self-emulsifying carriers that improve solubility and absorption. Used for poorly water-soluble drugs (e.g., curcumin and resveratrol).
    4. Microencapsulation & Nanoencapsulation: Powdered active ingredients are encapsulated in micro or nano-particles before being dispersed in the Soft gel fill matrix. This type of encapsulation enhances stability and bioavailability.
    5. Complexation with Cyclodextrins: Improves solubility of hydrophobic active ingredients.

 

Advantages of Soft gel Encapsulation for Powders

Improved Bioavailability – Especially for poorly soluble active ingredients.

Enhanced Stability – Protects active ingredients from moisture, oxidation, and degradation.

Controlled Release Options– Using specific formulation techniques.

Better Patient Compliance – Easier to swallow than tablets/capsules.

 

Challenges and Considerations

  • Compatibility with Fill Matrix – Powder should remain stable and not react with oils/solvents.
  • Gelatin or Vegan Alternatives – Soft gels can be made from animal gelatin or plant-based polymers.
  • Manufacturing Complexity – Specialized equipment is required.
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